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Preparation of paraherquamide labeled with deuterium or tritium

✍ Scribed by Timothy A. Blizzard; Avery Rosegay; Helmut Mrozik; Michael H. Fisher

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
173 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Deprotonation of paraherquamide (1a) at C‐24 and subsequent deuteration (or tritiation) is described. The procedure afforded 24‐^2^H‐paraherquamide (1b) with 66% deuterium incorporation at C‐24. Modification of the deuteration procedure to allow the introduction of tritium resulted in the preparation of 24‐^3^H‐paraherquamide (1c) with specific activity 3.7 Ci/mmol.

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