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Synthesis of tritium labelled [2′,6′]-L-tyrosine

✍ Scribed by W. Augustyniak; R. Kański; M. Kańska

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
85 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of a specifically ring labelled isotopomer of L‐tyrosine, (L‐Tyr), using a combination of chemical and enzymatic methods is reported. The tritium labelled [2′,6′]‐L‐Tyr has been synthesized via catalytic exchange of phenol with tritiated water in the presence of K~2~PtCl~4~, reverse acid catalysed removal of tritium from the o‐ and p‐positions of phenol, and subsequent condensation of the resulting [3′,5‐^3^H~2~]‐phenol with S‐methyl‐L‐cysteine using the enzyme β‐tyrosinase from Citrobacter freundii. Copyright © 2004 John Wiley & Sons, Ltd.

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