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Synthesis of tritium labeled O-ethyl-D-tyrosine and phenylalanine

✍ Scribed by Scott W. Landvatter; J. Richard Heys; Stephen G. Senderoff

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 337 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580240406

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✦ Synopsis

Two amino acids, 1-BOC-0-ethyl-P-tyrosine and 1-BOC-phenylalanine, have been synthesized in tritium labeled form via exchange with tritium gas over catalyst on an unlabeled precursor and dehydrohalogenation on an iodinated precursor respectively.

The tyrosine derivative has been obtained in specific activities of 4 -7 Cilrnmol; tritium NMR indicates that at least 80% of the tritium resides in the benzylic position of the molecule. The phenylalanine has been synthesized with a specific activity of greater than 35 Ci/mmol.

Tritium NMR confirms specific tritium/iodine replacement in the position.

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