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Synthesis of tritium labeled (±) 15-deoxyspergualin trihydrochloride

✍ Scribed by D. D. Dischino; D. J. Cook; M. G. Saulnier; M. A. Tepper

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
401 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Tritium labeled (±) 15‐deoxyspergualin, (±)‐7‐[(aminoiminomethyl) amino]‐N‐[2‐[[4‐[(3‐aminopropyl) amino]butyl]amino]‐1‐hydroxy‐2‐oxoethyl][4,5‐^3^H~2~]heptanamide trihydrochloride was prepared from the acid catalyzed condensation of 7‐guanidino[4,5‐^3^H~2~] heptanamide hydrochloride and glyoxyloylspermidine dihydrochloride in a total yield of 14.5%. The radiochemical purity was determined to be 91.1% and 95.4% on two different HPLC systems.

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