Recent i n v e s t i g a t i o n s concerning t h e o x i d a t i v e metabolism of b e n z o k lpyrene (Be) have implicated various epoxides as intermediates [l].
Synthesis of 3H-labeled environmentla carcinogens: Cyclopenta[c,d]pyrene-G-3H
✍ Scribed by P. H. Ruehle; A. B. Susàn; J. C. Wiley Jr.
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 148 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2135
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## Abstract The preparation of [^3^H]Sch 727965 from unlabeled compound and tritiated water was base catalyzed. Diethyl [^13^C~3~]malonate was used to prepare [^13^C~3~]Sch 727965 in five steps in 21.8% overall yield. In a similar manner, [^14^C]Sch 727965 was prepared in five steps from diethyl [2
D e f i n i t i v e s t u d i e s concerning t h e o x i d a t i v e metabolism or b e n z o k l p y r e n e (BP) n e c e s s i t a t e s t h e a v a i l a b i l i t y of h i g h l y p u r e r a d i ol a b e l e d oxygenated d e r i v a t i v e s [l]. Since 3-, 7-, and 9-hydroxybenzob]pyrenes (3-, 7
## Abstract ^2^H and ^3^H labelled Sch 40120 were prepared by Pt catalysed exchange with isotopic water. D7‐Sch 40120 was obtained in two exchanges in 53% yield and ^3^H‐Sch 40120 was prepared by a single exchange at a specific activity of 19.8 Ci/mmole. ^14^C‐Sch 40120 was prepared in 4 steps from
3H-Sch 47949, racemic 3H-Sch 48461, was prepared at a specific activity of 40 mCi/mmole by Pt catalysed exchange with tritiated water. 3H-Sch 48461 was prepared at a specific activity of 64.6 Ci/mmole by a Pd/C catalysed reduction of an olefinic intermediate. 14C-Sch 48461 was prepared in 8 steps fr