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Labeled metabolites of polycyclic aromatic hydrocarbons III. 3-,7-, and 9-hydroxybenzo [a] pyrenes-G-3H

✍ Scribed by W. P. Duncan; Edward J. Ogilvie II; James F. Engel

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
128 KB
Volume
11
Category
Article
ISSN
0022-2135

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✦ Synopsis

D e f i n i t i v e s t u d i e s concerning t h e o x i d a t i v e metabolism or b e n z o k l p y r e n e (BP) n e c e s s i t a t e s t h e a v a i l a b i l i t y of h i g h l y p u r e r a d i ol a b e l e d oxygenated d e r i v a t i v e s [l]. Since 3-, 7-, and 9-hydroxybenzob]pyrenes (3-, 7-, and 9-HOBP) have been i m p l i c a t e d i n such s t u d i e s [Z], t h e need f o r t h e s e r a d i o l a b e l e d compounds i s e v i d e n t .

📜 SIMILAR VOLUMES

Labeled metabolites of polycyclic aromat
Labeled metabolites of polycyclic aromatic hydrocarbons. VI. Trans-7,8-dihydrobenzo[a]pyrene-7,8,diol-G-3H and (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-G-3H
✍ Daniel J. McCaustland; Daniel L. Fischer; W. P. Duncan; Edward J. Ogilvie; James 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 294 KB

## Abstract The syntheses of trans‐7,8‐dihydrobenzo[a]pyrene‐7,8‐diol‐G‐^3^H (V) and (±)‐7α, 8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]pyrene‐G‐^3^H (VI) are described. The specific activities of V and VI were 158 mCi/mmole and 220 mCi/mmole, respectively. The key intermediate, trans‐7,8

Stablity upon storage, analysis and puri
Stablity upon storage, analysis and purification of 14C- and 3H-labeled polycyclic aromatic hydrocarbons (PAH) and their metabolites
✍ Alexander B. Susàn; Timothy P. Rohrig; James C. Wiley Jr. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 287 KB

## Abstract The studies on the stability, analysis and purification of several ^14^C‐ and ^3^H‐labeled polycyclic aromatic hydrocarbons such as benzo[a]‐pyrene, benzo[__e__]pyrene, and dibenz[__a__,__c__]anthracene and their metabolites such as dihydrodiols, phenols, and tetrahydrodiol epoxides are

Labeled metabolites of polycyclic aromat
Labeled metabolites of polycyclic aromatic hydrocarbons. V. trans-7,8-dihydrobenzo[a]pyrene-7,8-diol-7-14C and (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-7-14C
✍ Daniel J. McCaustland; W. P. Duncan; James F. Engel 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 245 KB

## Abstract trans‐7,8‐Dihydrobenzo[a]pyrene‐7,8‐diol‐7‐^14^C (VI) and (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]‐pyrene‐7‐^14^C (VII) were prepared at a specific activity of 53.9 mCi/mmole by a multi‐step synthetic sequence using K^14^CN as the labeled precursor. The overall radio