D e f i n i t i v e s t u d i e s concerning t h e o x i d a t i v e metabolism or b e n z o k l p y r e n e (BP) n e c e s s i t a t e s t h e a v a i l a b i l i t y of h i g h l y p u r e r a d i ol a b e l e d oxygenated d e r i v a t i v e s [l]. Since 3-, 7-, and 9-hydroxybenzob]pyrenes (3-, 7
Labeled metabolites of polycyclic aromatic hydrocarbons IV. 7-hydroxybenzo[a]pyrene-7-13c
✍ Scribed by W. P. Duncan; W. C. Perry; James F. Engel
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- French
- Weight
- 228 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0022-2135
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## Abstract trans‐7,8‐Dihydrobenzo[a]pyrene‐7,8‐diol‐7‐^14^C (VI) and (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]‐pyrene‐7‐^14^C (VII) were prepared at a specific activity of 53.9 mCi/mmole by a multi‐step synthetic sequence using K^14^CN as the labeled precursor. The overall radio
## Abstract The syntheses of trans‐7,8‐dihydrobenzo[a]pyrene‐7,8‐diol‐G‐^3^H (V) and (±)‐7α, 8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]pyrene‐G‐^3^H (VI) are described. The specific activities of V and VI were 158 mCi/mmole and 220 mCi/mmole, respectively. The key intermediate, trans‐7,8
Recent i n v e s t i g a t i o n s concerning t h e o x i d a t i v e metabolism of b e n z o k lpyrene (Be) have implicated various epoxides as intermediates [l].