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Labeled metabolites of polycyclic aromatic hydrocarbons IV. 7-hydroxybenzo[a]pyrene-7-13c

✍ Scribed by W. P. Duncan; W. C. Perry; James F. Engel


Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
228 KB
Volume
12
Category
Article
ISSN
0022-2135

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📜 SIMILAR VOLUMES


Labeled metabolites of polycyclic aromat
✍ W. P. Duncan; Edward J. Ogilvie II; James F. Engel 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 128 KB

D e f i n i t i v e s t u d i e s concerning t h e o x i d a t i v e metabolism or b e n z o k l p y r e n e (BP) n e c e s s i t a t e s t h e a v a i l a b i l i t y of h i g h l y p u r e r a d i ol a b e l e d oxygenated d e r i v a t i v e s [l]. Since 3-, 7-, and 9-hydroxybenzob]pyrenes (3-, 7

Labeled metabolites of polycyclic aromat
✍ Daniel J. McCaustland; W. P. Duncan; James F. Engel 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 245 KB

## Abstract trans‐7,8‐Dihydrobenzo[a]pyrene‐7,8‐diol‐7‐^14^C (VI) and (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]‐pyrene‐7‐^14^C (VII) were prepared at a specific activity of 53.9 mCi/mmole by a multi‐step synthetic sequence using K^14^CN as the labeled precursor. The overall radio

Labeled metabolites of polycyclic aromat
✍ Daniel J. McCaustland; Daniel L. Fischer; W. P. Duncan; Edward J. Ogilvie; James 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 294 KB

## Abstract The syntheses of trans‐7,8‐dihydrobenzo[a]pyrene‐7,8‐diol‐G‐^3^H (V) and (±)‐7α, 8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]pyrene‐G‐^3^H (VI) are described. The specific activities of V and VI were 158 mCi/mmole and 220 mCi/mmole, respectively. The key intermediate, trans‐7,8