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Synthesis of 3H-, 13C3-, and 14C-labeled Sch 727965

✍ Scribed by C. Flader Lavey; D. Hesk; D. Koharski; V. Truong; P. McNamara

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
152 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The preparation of [^3^H]Sch 727965 from unlabeled compound and tritiated water was base catalyzed. Diethyl [^13^C~3~]malonate was used to prepare [^13^C~3~]Sch 727965 in five steps in 21.8% overall yield. In a similar manner, [^14^C]Sch 727965 was prepared in five steps from diethyl [2‐^14^C]malonate in 11.1% radiochemical yield. Copyright Β© 2010 John Wiley & Sons, Ltd.

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