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Synthesis of 3H, 14C and 13C6 labelled Sch 58235

✍ Scribed by D. Hesk; G. Bignan; J. Lee; J. Yang; K. Voronin; C. Magatti; P. McNamara; D. Koharski; S. Hendershot; S. Saluja; S. Wang

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
130 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

^3^H‐Sch 58235 was prepared at a specific activity of 29.1 Ci/mmol by Ir(COD)(Cy~3~P)PyPF~6~ catalysed exchange with tritium gas. ^14^C‐Sch 58235 was prepared in three steps from p‐hydroxy[ring‐U‐^14^C]benzaldehyde with an overall radiochemical yield of 21%. ^13^C~6~‐Sch 58235 was similarly prepared in three steps from p‐hydroxy[ring‐U‐^13^C~6~]benzaldehyde in an overall yield of 41%. Copyright Β© 2002 John Wiley & Sons, Ltd.

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