✦ LIBER ✦

Synthesis of 3H, 14C and 2H4 labelled SCH 211803

✍ Scribed by D. Hesk; K. Voronin; P. McNamara; P. Royster; D. Koharski; S. Hendershot; S. Saluja; V. Truong; T. M. Chan

Publisher: John Wiley and Sons
Year: 2007
Tongue: French
Weight: 137 KB
Volume: 50
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1206

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✦ Synopsis

Abstract

[^3^H]SCH 211803, at a specific activity of 1.56 Ci/mmol, was prepared by direct exchange with tritiated water and platinum metal. [^2^H~4~]SCH 211803 was prepared from [^2^H]formaldehyde in a seven step synthesis in 10% yield. [^14^C]SCH 211803 was prepared from N‐benzyl‐4‐hydroxy[2‐^14^C]piperidine in a four‐step synthesis in 35% radiochemical yield. Additionally a high specific activity batch of [^3^H]SCH 211803 was prepared by Ru(Ph~3~P)~3~Cl~2~ catalysed exchange with 90 at% tritiated water to a specific activity of 35 Ci/mmol. Copyright © 2007 John Wiley & Sons, Ltd.

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