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Synthesis of 2-14c-labelled 3H-1,4-benzodiazepines

✍ Scribed by Z. S. Tegyey; G. Maksay; L. Ötvös

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
311 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

2-14C-oxazepam (z) d 4 C -(+)and -(-1 -7-chloro-l--methyl-5-phenyl-1,3,4,5-tetrahydro-3H-l,4-benzodiazepine-2--one (s and 2) as well as 2-14C-7-chloro-4-carbamoyl-l-methyl--5-phenyl-1,3,4,5-tetrahydro-3H-l,4-benzodiazepine-2-one (9-1

were synthesised from ~arbobenzoxy-glycine-1-~~C. The overall radiochemical yields from carbobenz~xy-glycine-l-~~C were 28.9 % ( I ) , 9.5 8 (86 and g ) and 25.3 8 (91, respectively.

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