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Synthesis of N-(2,3-dihydro-1-[14C]methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-benzamide and N-(2,3-dihydro-1-[14C]methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-N-[14C]methyl-benzamide as novel carbon-14 labelled CCK antagonists

✍ Scribed by Hojatollah Matloubi; Ali Khalaj; Reza Dowlatabadi; Gholamhossein Shirvani

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
74 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Two benzodiazepine CCK antagonists N‐(2,3‐dihydro‐1‐[^14^C]methyl‐2‐oxo‐5‐phenyl‐1H 1,4‐benzodiazepin‐3‐yl)‐benzamide 2 and N‐(2,3‐dihydro‐1‐[^14^C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐[^14^C]methyl‐benzamide 3 were synthesized in high yields through the reaction of N‐(2,3‐dihydro‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐benzamide 1 with [^14^C] methyl iodide in different situations. Copyright © 2002 John Wiley & Sons, Ltd.

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