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Synthesis of 1, 3-dihydro-1-methyl-7-nitro-5-phenyl-2H-1, 4-benzodiazepin-2-one-5-14c (nimetazepam-5-14C)

✍ Scribed by A. Yoshitake; Y. Makari; M. Endo

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
243 KB
Volume
8
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis from carbon‐^14^C dioxide of 1, 3‐dihydro‐1‐methyl‐7‐nitro‐5‐phenyl‐2H‐1, 4‐benzodiazepin‐2‐one‐5‐^14^C (I) for use in metabolic studies has been described. The synthesis was achieved by the sequence shown in figure 1. The overall yield of labelled nimetazepam (I) was nearly 36%.

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