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Synthesis of carbon-14 labeled 1, 4-benzodiazepines

✍ Scribed by Richard S. P. Hsi

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
248 KB
Volume
9
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Reaction of 7‐chloro‐1, 3‐dihydro‐5‐phenyl‐2H‐1, 4‐benzodiazepine ‐2‐thione (Ia) and 7‐chloro‐5‐(2‐chlorophenyl)‐1, 3‐dihydro‐2H, 1, 4‐benzodiazepine‐2‐thione (Ib) with hydrazine produces. respectively, 7‐chloro‐5‐phenyl‐3H‐1, 4‐benzo‐diazepin‐2‐yl hydrazin (IIa) and 7‐chloro‐5(2‐chlorphenyl)‐3H‐1, 4‐benzodiaze‐pin‐d‐ylhydrazine (IIb). Acetylation of IIa and IIb with N‐acetyl ‐ 1^14^C‐imida‐zole affords acetic acid‐1‐^14^C 2‐(7‐chloro‐5‐phenyl‐3H‐1, 4‐benzodiazenpin‐2‐yl) hydrazide (IIIa) and acetic acid‐1‐^14^C 2‐[7‐chloro‐5‐(2‐chlorphenyl) ‐3H‐1, 4‐benzodiazepine‐2‐yl] hydrazide (IIIb). Compounds IIIa and IIIb are thermally cyclised to give 8‐chloro‐1‐methyl‐6‐phenyl‐4H‐s‐triazol [4, 3] [1, 4] benzodiase‐pine‐1‐^14^c (IVa) and 8‐chloro‐6 (2‐chlorophenyl)‐1‐methyl‐4H‐s‐trizolo[4, 3‐a] ‐[1, 4] benzodiazepine ‐1‐^14^C (IVb).

📜 SIMILAR VOLUMES

Synthesis of carbon-14 labeled 1,4-benzo
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✍ Richard S. P. Hsi; Wayne T. Stolle 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 341 KB

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## Abstract A group of radioactive 1,4‐benzodiazepine derivatives have been synthesized from glycine‐1‐^14^C. The subject compounds are labeled with carbon‐14 in the 2‐position of the 1,4‐benzodiazepine ring system.

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✍ Hojatollah Matloubi; Ali Khalaj; Reza Dowlatabadi; Gholamhossein Shirvani 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 74 KB

## Abstract Two benzodiazepine CCK antagonists __N__‐(2,3‐dihydro‐1‐[^14^C]methyl‐2‐oxo‐5‐phenyl‐1H 1,4‐benzodiazepin‐3‐yl)‐benzamide **2** and __N__‐(2,3‐dihydro‐1‐[^14^C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐[^14^C]methyl‐benzamide **3** were synthesized in high yields through the reac

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