The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring. In each c
Synthesis of carbon-14 labeled 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
✍ Scribed by Andre Castonguay; Stephen S. Hecht
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 227 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2135
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## Abstract Urinary metabolites of the tobacco‐specific nitrosamine 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years before di
The expression profile of adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice was compared with that of normal lung tissue by suppression subtractive hybridization (SSH). The mRNAs of surfactant-associated protein A (SP-A) and lysozyme showed characteristically higher
## Abstract Reaction of 7‐chloro‐1, 3‐dihydro‐5‐phenyl‐2H‐1, 4‐benzodiazepine ‐2‐thione (Ia) and 7‐chloro‐5‐(2‐chlorophenyl)‐1, 3‐dihydro‐2H, 1, 4‐benzodiazepine‐2‐thione (Ib) with hydrazine produces. respectively, 7‐chloro‐5‐phenyl‐3H‐1, 4‐benzo‐diazepin‐2‐yl hydrazin (IIa) and 7‐chloro‐5(2‐chlorp
## Abstract The synthesis of high specific activity tritium‐labeled 4‐(acetoxymethylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone is reported. This compound was prepared by tritiation of 4‐(acetoxymethylnitrosamino)‐1‐[3‐(5‐bromo)‐pyridyl]‐1‐butanone (5‐BrNNKOAc) in the presence of 10% Pd/C catalyst, yield
## Abstract ## BACKGROUND In the United States, Blacks who smoke cigarettes have a higher mean blood concentration of the nicotine metabolite cotinine than White smokers. It has not been determined whether there are racial differences in the exposure to the cigarette smoke carcinogen 4‐(methylnitr