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Synthesis of 4- (methylnitrosamino)-1- (3-pyridyl)-1-butanone, 4- (carbethoxynitrosamino)-1- (3-pyridyl)-1-butanone, and N′ -nitrosonornicotine labelled with tritium in the pyridine ring

✍ Scribed by James C. Wiley Jr.; David H. T. Chien; Nancy A. Nungesser; Dorothy Lin; Stephen S. Hecht

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
349 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring.

In each case, the tritium labelled compound was prepared by catalytic tritium replacement of the corresponding brominated precursor.

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