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An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

✍ Scribed by Lisa A. Peterson; Thomas E. Spratt; Weifeng Shan; Lijuan Wang; Witold Subotkowski; Robert Roth

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
82 KB
Volume
44
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of high specific activity tritium‐labeled 4‐(acetoxymethylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone is reported. This compound was prepared by tritiation of 4‐(acetoxymethylnitrosamino)‐1‐[3‐(5‐bromo)‐pyridyl]‐1‐butanone (5‐BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods. Copyright © 2001 John Wiley & Sons, Ltd.

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