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Synthesis of [3H], [13C215N] and [14C]Sch 66336 (Sarasar™)

✍ Scribed by D. Hesk; D. Cesarz; C. Magatti; K. Voronin; C. Lavey; P. McNamara; D. Koharski; S. Saluja; S. Hendershot; H. Pham; V. Truong

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
141 KB
Volume
48
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[^3^H]Sch 66336 was prepared at a specific activity of 1.35 Ci/mmol by Ru(Ph~3~P)~3~Cl~2~ catalysed exchange with tritiated water. [^13^CN]Sch 66336 was synthesized from potassium [^13^C]cyanide and [^13^C^15^N~2~]urea in 29% overall yield from potassium [^13^C]cyanide. [^14^C]Sch 66336 was synthesized from potassium [^14^C]cyanide in 31% yield. A second synthesis, from N‐Boc‐4‐hydroxy[^14^C]piperidine, gave [^14^C]Sch 66336 labelled in a different site in 19% overall yield. Copyright © 2004 John Wiley & Sons, Ltd.

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