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Synthesis of [2,4-3H] 17β-dihydroequilin sulfate

✍ Scribed by Bhagu R. Bhavnani

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
269 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[2,4‐^3^H] 17β‐dihydroequilin‐3‐sulfate ammonium salt suitable for in vivo pharmacokinetic studies was synthesized from [2,4‐^3^H] equillin. Sulfation of [2,4‐^3^H] equillin with pyridine‐chiorosulfonic acid mixture gave in high yields [2,4‐^3^H] equilin sulfate, which was then reduced with sodium borohydride to yield [2,4‐^3^H] 17β‐dihydroequilin sulfate. The reduction was sterospecific and no 17α‐reduced products were formed.

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