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Synthesis and purification of betamethasone-1,2,4−3H and betamethasone-1,2,4−3H 17-benzoate

✍ Scribed by Edward J. Merrill; Gerald G. Vernice

Publisher: John Wiley and Sons
Year: 1971
Tongue: French
Weight: 343 KB
Volume: 7
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590070417

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✦ Synopsis

Betaniethasone 21 -acetate was catalytically reduced with tritium. The crude product was oxidized with 2,3-dichloro-5,6-dicyano-1,4benzoquinone ( D D Q ) to betamethasone-I,2,4JH 21-acetate. Hydrolysis gave bet~methasone-1,2,4-~H, which, when allowed to react with trimethylorthobenzoate, gave both betarnethasone-l,2,4-3H I7,21-methylorthobenzoate and betamethasone-1,2,4-3H 17,21orthobenzoate. Selective hydrolysis of the betamethasone-1,2,4-3H methylorthobenzoate gave the desired betamethasone-1,2,4-3H 17-benzoate.

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