𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of betamethasone-l,2-3h2 17-benzoate

✍ Scribed by T. Kobari; S. Watanabe; S. Ikegami

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
241 KB
Volume
11
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A new convenient method for the preparation of the title compound is described. The method consists of selective tritiation of betamethasone 17‐benzoate (9α‐fluoro‐11β,17,21‐trihydroxy‐16β‐methyl‐1,4‐pregnadiene‐3,20‐dione 17‐benzoate) (1) with the use of tris(triphenylphosphine)rhodium chloride as catalyst, followed by dehydrogenation with 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ).

A favorable overall radiochemical yield is obtained.

📜 SIMILAR VOLUMES

Synthesis and purification of betamethas
Synthesis and purification of betamethasone-1,2,4−3H and betamethasone-1,2,4−3H 17-benzoate
✍ Edward J. Merrill; Gerald G. Vernice 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 343 KB

Betaniethasone 21 -acetate was catalytically reduced with tritium. The crude product was oxidized with 2,3-dichloro-5,6-dicyano-1,4benzoquinone ( D D Q ) to betamethasone-I,2,4JH 21-acetate. Hydrolysis gave bet~methasone-1,2,4-~H, which, when allowed to react with trimethylorthobenzoate, gave both b

The synthesis of [2-3H2] taurine and [2-
The synthesis of [2-3H2] taurine and [2-3H2] hypotarine
✍ J. H. Fellman 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 146 KB

## Abstract The synthesis of [2‐^3^H~2~]‐2‐aminoethanesulfonate [2‐^3^H]‐taurine by the reduction of cyanomethanesulfonic acid with tritium gas is described. The conversion of [2‐^3^H]‐taurine and its ^14^C and ^35^S isotopic forms to 2‐aminoethanesulfinate (hypotaurine) was accomplished by convert

Synthesis of [2,4-3H] 17β-dihydroequilin
Synthesis of [2,4-3H] 17β-dihydroequilin sulfate
✍ Bhagu R. Bhavnani 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 269 KB

## Abstract [2,4‐^3^H] 17β‐dihydroequilin‐3‐sulfate ammonium salt suitable for __in vivo__ pharmacokinetic studies was synthesized from [2,4‐^3^H] equillin. Sulfation of [2,4‐^3^H] equillin with pyridine‐chiorosulfonic acid mixture gave in high yields [2,4‐^3^H] equilin sulfate, which was then redu