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Synthesis of 1,3-thiazole and 1,2,4-oxadiazole substituted spiro[3H-indole-3,2′-thiazolidine]-2,4′(1H)-diones

✍ Scribed by Uday C. Mashelkar; Deepak M. Rane; Rajesh S. Kenny

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
354 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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Some new derivatives of spiro[3__H__‐indole‐3,2′‐thiazolidine]‐2,4′(1__H__)‐dione with the heterocyclic ring such as substituted thiazole and 1,2,4‐oxadiazole attached to the indolinone ring via CH~2~ linkage has been synthesized in moderate yields. The synthesis have been carried out by making use of the reactivity of the NH group of the indolinone moiety present in spiro[3__H__‐indole‐3,2′‐thiazolidine]‐2,4′(1__H__)‐dione.

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