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Synthesis of [7-3H]-3β, 16β-dihydoxy-5-androsten-17-one

✍ Scribed by Ronald B. Franklin; Randolph J. McMurtry; Sidney D. Nelson

Publisher: John Wiley and Sons
Year: 1981
Tongue: French
Weight: 352 KB
Volume: 18
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580180812

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✦ Synopsis

Abstract

A method has been described for the synthesis of tritiated [7‐^3^H]‐3β,16β‐dihydroxy‐5‐androsten‐17‐one of high specific activity starting from [7‐^3^H]‐5‐androsten‐17‐one. The identity of the radioactive steroid was established by thin layer chromato‐graphy, gas chromatography and gas chromatography combined with mass spectroscopy. The radiolabelled steroid may be used to study its disposition and metabolism in experimental animals and also to further investigate the potential role of 3β,16β‐dihydroxy‐5‐androsten‐17‐one in patients with low renin essential hypertension.

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