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The microsynthesis of 1,2–[3H]–11β-hydroxyandrost-4-ene-3,17-dione

✍ Scribed by M. Wilkinson; N. Deshpande


Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
136 KB
Volume
7
Category
Article
ISSN
0022-2135

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✦ Synopsis


Very little is known regarding the biogenesis and the factors controlling the synthesis of 1 1 /3-hydroxyandrost-4-ene-3,17-dione (I), one of the androgens secreted by the human adrenal gland. Recent in vivo infusion studies


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Catalytic reduction of 3β-hydroxyandrost
✍ Yusuf J. Abul-Hajj 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 349 KB

Catalytic reduction of 3j3-hydroxyandrost-4-ene-l7-one (I) with tritium gas gave a mixture of 3B-hydroxy-5a-androstane-17-one (11) and 3~-hydroxy-5cc-androstane-l7-one ( 1 1 1 ) . Oxidation of compound 1 1 followed by alkaline equilibration resulted in 37 % loss of label from position 4. 5a-Androsta