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Synthesis of 14C-labelled 1-(3,5-bis-trifluoromethyl)-phenyl-4-methyl thiosemicarbazide, C 2696-GO

✍ Scribed by R. K. Maller; K. Nagarajan; H. Zoebeli

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
368 KB
Volume
22
Category
Article
ISSN
0022-2135

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✦ Synopsis

For pharmacokinetic and metabolism s t u d i e s i n e x p e r i m e n t a l animals C 2 6 9 6 4 0 was l a b e l l e d i n i t i a l l y w i t h 14C on t h e t h i o c a r b o n y l carbon of t h e t h i o s e m i c a r b a z i d e moiety o f t h e molecule, having a s p e c i f i c a c t i v i t y o f 3.14 pCi/mg, i n a r a d i o c h e m i c a l y i e l d of 43%, based on t h e s t a r t i n g potassium [ 14C] t h i o c y a n a t e . C 2 6 9 6 4 0 a l t e r n a t i v e l y l a b e l l e d with 14C on one o f t h e t r i f luoromethyl groups, having a s p e c i f i c a c t i v i t y of 3.6 pCi/mg was a l s o s y n t h e s i z e d i n an o v e r a l l r a d i o c h e m i c a l y i e l d of 5.W, s t a r t i n g from Ba[ clog.

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