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Synthesis of 3-methyl-4-phenyl-3-butenamide-1-14C and N,N-dideutero-3-methyl-4-phenyl-3-butenamide

✍ Scribed by U. Valcavi

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
230 KB
Volume
10
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The syntheses of 3‐methyl‐4‐phenyl‐3‐butenamide, an hypolipemic compound, labelled 1‐^14^C (VIII) and N,N‐dideutero (XI) are described. The 2‐methyl‐3‐phenyl‐2‐propenyl chloride (VI), reacting with cuprous cyanide‐^14^C, gave the 3‐methyl‐4‐phenyl‐3‐butenonitrile‐1‐^14^C (VII) which, treated with hydrochloric acid‐water, gave the 3‐methyl‐4‐phenyl‐3‐ butenamide‐1‐^14^C (VIII). The 3‐methyl‐4‐phenyl‐3‐butenonitrile (X), treated with hydrochloric acid‐D~2~O, gave the N,N‐dideutero‐3‐methyl‐4‐phenyl‐3‐butenamide (XI).

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