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Synthesis of 14C-labelled 1-(4-chlorobenzyl)-3-methyl-3-(2-hydroxyethyl)-thiourea

✍ Scribed by K. Esses-Reiter; J. Reiter

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
164 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

1‐(4‐Chlorobenzyl)‐3‐methyl‐3‐(2‐hydroxyethyl)‐thiourea labelled with ^14^C at its urea group was synthesised starting from potassium cyanide‐^14^C, via potassium thiocyanate‐^14^C, 4‐chlorobenzyl‐thiocyanate‐^14^C and 4‐chlorobenzyl‐isothiocyanate‐^14^C. The conditions of the isomerisation of 4‐chlorobenzyl‐thiocyanate‐^14^C to 4‐chlorobenzyl‐isothiocyanate‐^14^C were studied in detail.

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