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Synthesis of 14C-labelled myosmine, [2′-14C] -3-(1-pyrrolin-2-yl)pyridine

✍ Scribed by Stefan Tyroller; Wolfgang Zwickenpflug; Elmar Richter

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
71 KB
Volume
46
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

^14^C‐Labelled myosmine ([2′‐^14^C]‐3‐(1‐pyrrolin‐2‐yl)pyridine) was synthesized for autoradiography studies starting from [carboxyl‐^14^C]‐nicotinic acid by initial esterification of the latter in the presence of 1,1,1‐triethoxyethane. Without any purification the ethyl nicotinate formed was directly reacted with N‐vinyl‐2‐pyrrolidinone in the presence of sodium hydride, yielding ^14^C‐labelled myosmine. The product was purified by silica gel column chromatography. The radiochemical yield was 15% and the specific activity 55.2 mCi/mmol. Copyright © 2003 John Wiley & Sons, Ltd.

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