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Synthesis of 14C-labelled 4-(2-hydroxy-3-isopropylaminopropoxy)-2-methyl-indole (mapindolol)

✍ Scribed by V. O. Illi; J. Heindl; J. Balzer; W. Schwartz

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
157 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Mepindolol, a potent ß‐adrenoceptor blocking agent, was labelled with ^14^C by two different routes yielding the 2‐[^14^C]methyl and [2‐^14^C] products. While the first alternative was abandoned because of low overall yield, the latter route provided mepindolol with a specific activity of 2.06 GBq/mmole (55.8 mCi/mmole) and in a radiochemical yield of 40% starting from Ba^14^CO~3~.

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