𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 14C-labelled 2-(3-benzoylphenoxy)-2-methyl propionic acid (LF.599)

✍ Scribed by C. Luu Duc; Cl. Charlon; J. P. Bourgogne; R. Sornay


Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
147 KB
Volume
18
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis


Abstract

The title product was labelled with ^14^C at the ketone group, from 3‐methoxybromobenzene in six steps. Complete synthetic techniques of the labelled drug are presented.


📜 SIMILAR VOLUMES


Preparation of 14C labeled β-aminoisobut
✍ J. H. Lukas; G. B. Gerber 📂 Article 📅 1965 🏛 John Wiley and Sons 🌐 French ⚖ 81 KB

Preparation of 14C labeled p-aminoisobutyric acid (3 Amino-2 methyl-propionic acid, 314C) \* In the course of studies on the catabolism of thymidine the need emerged to study in greater detail its metabolite (l), p aminoisobutyric acid (BAIBA). This substance, labeled with 14C in the 3-C position,

Synthesis of 14c-labeled 2,2-dichloropro
✍ F. S. Tanaka; R. G. Wien 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 413 KB 👁 1 views

## Abstract A widely used herbicide, 2,2‐dichloropropionic acid (dalapon), was synthesized with ^14^C‐labeling in the C‐1 or C‐2 positions. The carboxyl labeled material was prepared in 55% yield by carbonation of 1,1‐dichloro‐ethyllithium at approximately −104°. Starting with trichloroacetic acid,

Synthesis of 14C-labelled 4-(2-hydroxy-3
✍ V. O. Illi; J. Heindl; J. Balzer; W. Schwartz 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 157 KB

## Abstract Mepindolol, a potent ß‐adrenoceptor blocking agent, was labelled with ^14^C by two different routes yielding the 2‐[^14^C]methyl and [2‐^14^C] products. While the first alternative was abandoned because of low overall yield, the latter route provided mepindolol with a specific activity

Synthesis of 14C-labelled 1-(4-chloroben
✍ K. Esses-Reiter; J. Reiter 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 164 KB

## Abstract 1‐(4‐Chlorobenzyl)‐3‐methyl‐3‐(2‐hydroxyethyl)‐thiourea labelled with ^14^C at its urea group was synthesised starting from potassium cyanide‐^14^C, via potassium thiocyanate‐^14^C, 4‐chlorobenzyl‐thiocyanate‐^14^C and 4‐chlorobenzyl‐isothiocyanate‐^14^C. The conditions of the isomerisa

Synthesis of 3-cyano-4-methyl-5(14C)-met
✍ I. L. Honigberg; N. M. Meltzer; C. D. Blanton Jr. 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 181 KB 👁 1 views

A synthesis of 3-cyano-4-methyl-5 ( 14 C)-methyl-2-(5-14C)pyrrolyloxamic acid is described. The compound, having specific activity of 66.7 pCi/mmole, was obtained in 19.68% overall yield from uniformly labelled 14C-l-alanine. 14 14 Key Words: 3-Cyano-4-methyl-5( C)-methyl-2-(5-C)pyrrolyloxamic acid,

Synthesis of 14C-labelled myosmine, [2′-
✍ Stefan Tyroller; Wolfgang Zwickenpflug; Elmar Richter 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 71 KB 👁 1 views

## Abstract ^14^C‐Labelled myosmine ([2′‐^14^C]‐3‐(1‐pyrrolin‐2‐yl)pyridine) was synthesized for autoradiography studies starting from [carboxyl‐^14^C]‐nicotinic acid by initial esterification of the latter in the presence of 1,1,1‐triethoxyethane. Without any purification the ethyl nicotinate form