Preparation of 14C labeled p-aminoisobutyric acid (3 Amino-2 methyl-propionic acid, 314C) \* In the course of studies on the catabolism of thymidine the need emerged to study in greater detail its metabolite (l), p aminoisobutyric acid (BAIBA). This substance, labeled with 14C in the 3-C position,
Synthesis of 14C-labelled 2-(3-benzoylphenoxy)-2-methyl propionic acid (LF.599)
✍ Scribed by C. Luu Duc; Cl. Charlon; J. P. Bourgogne; R. Sornay
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 147 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The title product was labelled with ^14^C at the ketone group, from 3‐methoxybromobenzene in six steps. Complete synthetic techniques of the labelled drug are presented.
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## Abstract A widely used herbicide, 2,2‐dichloropropionic acid (dalapon), was synthesized with ^14^C‐labeling in the C‐1 or C‐2 positions. The carboxyl labeled material was prepared in 55% yield by carbonation of 1,1‐dichloro‐ethyllithium at approximately −104°. Starting with trichloroacetic acid,
## Abstract Mepindolol, a potent ß‐adrenoceptor blocking agent, was labelled with ^14^C by two different routes yielding the 2‐[^14^C]methyl and [2‐^14^C] products. While the first alternative was abandoned because of low overall yield, the latter route provided mepindolol with a specific activity
## Abstract 1‐(4‐Chlorobenzyl)‐3‐methyl‐3‐(2‐hydroxyethyl)‐thiourea labelled with ^14^C at its urea group was synthesised starting from potassium cyanide‐^14^C, via potassium thiocyanate‐^14^C, 4‐chlorobenzyl‐thiocyanate‐^14^C and 4‐chlorobenzyl‐isothiocyanate‐^14^C. The conditions of the isomerisa
A synthesis of 3-cyano-4-methyl-5 ( 14 C)-methyl-2-(5-14C)pyrrolyloxamic acid is described. The compound, having specific activity of 66.7 pCi/mmole, was obtained in 19.68% overall yield from uniformly labelled 14C-l-alanine. 14 14 Key Words: 3-Cyano-4-methyl-5( C)-methyl-2-(5-C)pyrrolyloxamic acid,
## Abstract ^14^C‐Labelled myosmine ([2′‐^14^C]‐3‐(1‐pyrrolin‐2‐yl)pyridine) was synthesized for autoradiography studies starting from [carboxyl‐^14^C]‐nicotinic acid by initial esterification of the latter in the presence of 1,1,1‐triethoxyethane. Without any purification the ethyl nicotinate form