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Synthesis of 14c-labeled 2,2-dichloropropionic acid

✍ Scribed by F. S. Tanaka; R. G. Wien

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
413 KB
Volume
12
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A widely used herbicide, 2,2‐dichloropropionic acid (dalapon), was synthesized with ^14^C‐labeling in the C‐1 or C‐2 positions. The carboxyl labeled material was prepared in 55% yield by carbonation of 1,1‐dichloro‐ethyllithium at approximately −104°. Starting with trichloroacetic acid, the C‐2 labeled product was prepared in an overall yield of 39% by means of a 4‐step reaction sequence which involved the removal of a chlorine atom and the addition of a methyl group.

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