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Synthesis of 4-amino-3,2′ -dimethylbiphenyl-3-methyl-14C and 4-amino-2′-methylbiphenyl-2′-methyl-14C

✍ Scribed by Karam El-Bayoumy; Stephen S. Hecht


Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
373 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis


Abstract

The syntheses of 4‐amino‐3,2′‐dimethyl‐biphenyl‐3‐methyl‐^14^C, a potent carcinogen and mutagen, and 4‐amino‐2′‐methylbiphenyl‐2′‐methyl‐^14^C, an analogue having weaker activity, are described. In both cases, label was introduced with Cu^14^ CN.


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A synthesis of 3-cyano-4-methyl-5 ( 14 C)-methyl-2-(5-14C)pyrrolyloxamic acid is described. The compound, having specific activity of 66.7 pCi/mmole, was obtained in 19.68% overall yield from uniformly labelled 14C-l-alanine. 14 14 Key Words: 3-Cyano-4-methyl-5( C)-methyl-2-(5-C)pyrrolyloxamic acid,

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