A seven-step 'synthesis of 3-amino-l-methyl-9FJ-[4-l 'Clpyrido-[ 3,4-&] indole from DL-[methylene-"C] tryptophan and acetaldehyde is described.
Synthesis of 4-amino-3,2′ -dimethylbiphenyl-3-methyl-14C and 4-amino-2′-methylbiphenyl-2′-methyl-14C
✍ Scribed by Karam El-Bayoumy; Stephen S. Hecht
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 373 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The syntheses of 4‐amino‐3,2′‐dimethyl‐biphenyl‐3‐methyl‐^14^C, a potent carcinogen and mutagen, and 4‐amino‐2′‐methylbiphenyl‐2′‐methyl‐^14^C, an analogue having weaker activity, are described. In both cases, label was introduced with Cu^14^ CN.
📜 SIMILAR VOLUMES
A synthesis of 3-cyano-4-methyl-5 ( 14 C)-methyl-2-(5-14C)pyrrolyloxamic acid is described. The compound, having specific activity of 66.7 pCi/mmole, was obtained in 19.68% overall yield from uniformly labelled 14C-l-alanine. 14 14 Key Words: 3-Cyano-4-methyl-5( C)-methyl-2-(5-C)pyrrolyloxamic acid,
## Abstract Sodium [1‐^14^C] isobutyrate: 1 was obtained by carbonation of isopropyl magnesium bromide with ^14^CO~2~. From: 1 [1‐^14^C] isobutyryl chloride: 3 was prepared, which through the successive actions of diazomethane and hydrogen bromide gave rise to 1‐bromo 3 methyl [2‐^14^C] 2‐butanone:
## Abstract The title compound 9 was prepared by the route outlined in Scheme I. [^14^C]Thiourea (1) was condensed with ethyl 4‐bromo‐3‐oxo‐2‐methoxyiminoacetate (2), providing ethyl 2‐(2‐amino‐4‐[2‐^14^C]thiazolyl)‐2‐methoxyiminoacetate (3), as the pure Z‐isomer. Saponification gave the amino acid
## Abstract [^14^C]SR 33557 was synthesized in six steps and in an overall yield of 3.8% from sodium [^14^C]cyanide.