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Synthesis of 13C and 15N multilabeled 5-aminolevulinic acid

✍ Scribed by Katsumi Iida; Masahiro Kajiwara

Publisher: John Wiley and Sons
Year: 2002
Tongue: French
Weight: 78 KB
Volume: 45
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.541

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✦ Synopsis

Abstract

5‐[4‐^13^C,^15^N]‐ and 5‐[5‐^13^C,^15^N]Aminolevulinic acid (ALA) were simply synthesized in four steps by the condensation of [1‐^13^C,^15^N]‐ or [2‐^13^C,^15^N]glycine, respectively, with phthalic anhydride, followed by conversion to the chloride, coupling reaction with a three‐carbon unit and hydrolysis. Copyright © 2002 John Wiley & Sons, Ltd.

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