## Abstract 5‐[4‐^13^C,^15^N]‐ and 5‐[5‐^13^C,^15^N]Aminolevulinic acid (ALA) were simply synthesized in four steps by the condensation of [1‐^13^C,^15^N]‐ or [2‐^13^C,^15^N]glycine, respectively, with phthalic anhydride, followed by conversion to the chloride, coupling reaction with a three‐carbon
A new synthesis and NMR-spectroscopy of [15N-, 5,4-13C]-aminolevulinic acid
✍ Scribed by Bernhard Nitsche; Hans-Peter Köst; Edmund Cmiel; Siegfried Schneider
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 264 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
A new synthesis of i' 5N-, 5,4-13C1-aminolevulinic acid (ALA) starting from amorphous 13C is described. NMR-spectroscopic data ( HI 13C, 15N) of the product are presented.
📜 SIMILAR VOLUMES
## Abstract 5‐[4,5‐^13^C~2~]‐ and 5‐[1,5‐^13^C~2~]Aminolevulinic acid (ALA) have been synthesized by the Gabriel condensation of potassium phthalimide with ethyl bromo[1,2‐^13^C~2~]acetate (derived from [1,2‐^13^C~2~]acetic acid) or ethyl bromo[2‐^13^C]‐acetate (derived from sodium [2‐^13^C]acetate
## Abstract ^15^N NMR chemical shifts of 2‐aryl‐1,3,4‐oxadiazoles were assigned on the basis of the ^1^H–^15^N HMBC experiment. Chemical shifts of the nitrogen and carbon atoms in the oxadiazole ring correlate with the Hammett σ‐constants of substituents in the aryl ring (__r__^2^ ≥ 0.966 for N ato