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Synthesis of 5-[4,5-13C2]- and 5-[1,5-13C2]aminolevulinic acid

✍ Scribed by Katsumi Iida; Shinji Tokiwa; Toshihiro Ishii; Masahiro Kajiwara

Publisher: John Wiley and Sons
Year: 2002
Tongue: French
Weight: 98 KB
Volume: 45
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.583

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✦ Synopsis

Abstract

5‐[4,5‐^13^C~2~]‐ and 5‐[1,5‐^13^C~2~]Aminolevulinic acid (ALA) have been synthesized by the Gabriel condensation of potassium phthalimide with ethyl bromo[1,2‐^13^C~2~]acetate (derived from [1,2‐^13^C~2~]acetic acid) or ethyl bromo[2‐^13^C]‐acetate (derived from sodium [2‐^13^C]acetate), followed by conversion to the chloride, coupling reaction with 2‐ethoxycarbonylethylzinc iodide derived from ethyl 3‐iodopropionate or 2‐methoxy[^13^C]carbonylethylzinc iodide derived from methyl 3‐iodo[1‐^13^C]propionate (generated from potassium [^13^C]cyanide), and hydrolysis. Copyright © 2002 John Wiley & Sons, Ltd.

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