## Abstract 5β[4,5β^13^C~2~]β and 5β[1,5β^13^C~2~]Aminolevulinic acid (ALA) have been synthesized by the Gabriel condensation of potassium phthalimide with ethyl bromo[1,2β^13^C~2~]acetate (derived from [1,2β^13^C~2~]acetic acid) or ethyl bromo[2β^13^C]βacetate (derived from sodium [2β^13^C]acetate
Synthesis of 2-amino-1,5-dihydro-1-(methyl-13C)-4H-imidazol-4-one-5-13C (creatinine-13C2)
β Scribed by A. Cohen; H. H. Hertz; R. Schaffer; M. M. Welch; E. White
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 348 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0022-2135
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SYNTHESIS OF (2s , 4S)-[5-l 3C] LEUC INE , (2R ,4S)-[5-' 3C] LEUC I NE , AND (2RS)-[1 ,2-13C,] LEUCINE D. John Aberhart\* and Bruce H. W e i l l e r The Worcester Foundation f o r Experimental B i o l o g y Shrewsbury, Massachusetts 01545 SUMMARY (2RSY3S)-[4-13 ClVal i n e was d i a z o t i z e d an
## Abstract Nefopam hydrochloride (I), an analgesic agent, was labelled with carbonβ13 at Cβ1,3,4 and 6 positions for metabolic studies. The starting materials for the synthesis included commercially available phthalic acidβcarboxylβ^13^C~1~ (II) and 2βmethylaminoethylβ1,2β^13^C~2~ alcohol. The ext