Synthesis of [5′-13C]Ribonucleosides and 2′-Deoxy[5′-13C]ribonucleosides.
✍ Scribed by Etsuko Kawashima; Kaoru Umabe; Takeshi Sekine
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 52 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
## Abstract 5‐[4,5‐^13^C~2~]‐ and 5‐[1,5‐^13^C~2~]Aminolevulinic acid (ALA) have been synthesized by the Gabriel condensation of potassium phthalimide with ethyl bromo[1,2‐^13^C~2~]acetate (derived from [1,2‐^13^C~2~]acetic acid) or ethyl bromo[2‐^13^C]‐acetate (derived from sodium [2‐^13^C]acetate
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract 2′,3′‐Dideoxyinosine‐^13^C~5~ (ddI‐^13^C~5~) and the related 2′,3′‐dideoxyadenosine‐^13^C~5~ (ddA‐^13^C~5~) were prepared from (S)‐5‐[^13^C~5~]2,3‐dideoxyribonolactone 1. From a batch of this starting material ddI‐^13^C~5~ was made in 27% overall yield in seven steps and ddA‐^13^C~5~ in
Three selectively labeled propynes were prepared either with deuterium or carbon-13 at position 3 and doubly labeled with carbon-13 at positions 1 and 2 by an alkylation reaction from the corresponding labeled or unlabeled monolithio acetylides and dimethylsulfates. Their lithiation with nBuLi gave