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A convenient synthesis of 2′,3′-dideoxyinosine-13C5 and related 2′,3′-dideoxyadenosine-13C5

✍ Scribed by I. Victor Ekhato; Jay K. Rinehart

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
191 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

2′,3′‐Dideoxyinosine‐^13^C~5~ (ddI‐^13^C~5~) and the related 2′,3′‐dideoxyadenosine‐^13^C~5~ (ddA‐^13^C~5~) were prepared from (S)‐5‐[^13^C~5~]2,3‐dideoxyribonolactone 1. From a batch of this starting material ddI‐^13^C~5~ was made in 27% overall yield in seven steps and ddA‐^13^C~5~ in five steps and 14% overall yield. The known synthesis of ddI‐^13^C~5~ from glucose‐^13^C~6~ took 18‐steps~;~ therefore the present work is a substantial improvement. Copyright © 2010 John Wiley & Sons, Ltd.

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