Transport properties of 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (DDI) were characterized in the isolated rat choroid plexus. AZT and DDI competitively inhibited the active transport of [3H]benzylpenicillin, a prototypic organic anion, with Ki values of 85.4 +/- 13.1 and 155 +/- 22
13C NMR spectra of antiviral nucleosides' 3′-azido-3′-deoxythymidine, 2′,3′-dideoxyadenosine, 2′,3′-dideoxycytidine and 2′,3′-dideoxyinosine
✍ Scribed by G. W. Buchanan; K. Bourque
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 179 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
NMR chemical shifts and one-bond ' 3C-1 H couplings are reported for B'azido-3'-deoxythymidine, 2',3'-dideoxyadenosine, 2',3'-dideoxycytidine and 2 ' 3dideoxyinosine. Unambiguous assignments were made on the basis of results from 2D INADEQUATE experiments to establish the carbon-carbon connectivities.
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