2′-C-Branched Ribonucleosides. Part 2. Synthesis of 2′-C-β-Trifluoromethyl Pyrimidine Ribonucleosides.
✍ Scribed by Nan-Sheng Li; Xiao-Qing Tang; Joseph A. Piccirilli
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Nucleobase‐anion glycosylation of 6‐(methylthio)‐2‐azapurine (1) with 2‐deoxy‐3,5‐di‐__O__‐(p‐toluoyl)‐α‐D‐erythro‐pentofuranosyl chloride (2) yields the 2′‐deoxy‐β‐D‐ribofuranosides 3–5 stereoselectively. The distribution of regioisomers is as follows: N‐9 (32%); N‐2 (30%), and N‐7 (7%