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Synthesis of D,L-[2-15N,5-13C]glutamic acid

✍ Scribed by John C. Laiuppa; David M. Lemaster

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 281 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580331005

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✦ Synopsis

Abstract

A one‐pot procedure is described for the synthesis of D,L‐[2‐^15^N,5‐^13^C]glutamic acid from 2‐bromo‐4–butyrolactone utilizing potassium ^15^N‐phthalimide and potassium ^13^C‐cyanide as label sources. Following a two column purification procedure, the final product is obtained in 38% yield based on the equimolar label sources.

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