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Synthesis of [11C]-sarin

✍ Scribed by C. Prenant; C. Crouzel

Publisher: John Wiley and Sons
Year: 1990
Tongue: French
Weight: 218 KB
Volume: 28
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580280604

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✦ Synopsis

Abstract

[^11^C]‐acetone, prepared from ^11^CO~2~ and methyllithium, was reduced to [^11^C]‐isopropanol. The latter reacted with methylphosphonic acid difluoride in the presence of diisopropylamine, to yield [11C]‐sarin.

3.4 GBq (100 mCi) of [^11^C]‐sarin may be obtained from about 55.5 GBq (1.5 Ci) of ^11^CO~2~ in 40 minutes. The product purified by HPLC, is obtained with a specific radioactivity ranging from 22.2 to 33.3 GBq (600 to 900 mCi/μmol.).

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