## Abstract [^11^C]โacetone, prepared from ^11^CO~2~ and methyllithium, was reduced to [^11^C]โisopropanol. The latter reacted with methylphosphonic acid difluoride in the presence of diisopropylamine, to yield [11C]โsarin. 3.4 GBq (100 mCi) of [^11^C]โsarin may be obtained from about 55.5 GBq (1.
Synthesis of n.c.a.[11C]sarin
โ Scribed by C. Prenant; C. Crouzel
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 55 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2135
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๐ SIMILAR VOLUMES
## Abstract Synthetic routes for the synthesis of [^14^C] sarin and related nerve agents are described. Triethyl phosphite and [^14^C] methyl iodide are reacted in the MichaelisโArbusov reaction to produce diethyl methyl phosphonate which is converted to methylphosphonic acid by hydrolysis. After c
Synthesis o f specific labelled [methyl-14Clsarin. The synthesis of label led [methyl-14Clsarin, [14Clmethylphosphonofluoridic acid 1-methylethyl ester, was accomplished by another approach as for nonlabelled sarin in a tele-conducted reaction vessel. The purity was estimated by IR, GC, and GC-MS a
## Abstract Rapid chemical __syntheses of [carbonyl__โ ^11^C]melatonin and __N__โ[__carbonyl__โ ^11^C]acetylserotonin starting from [^11^C]carbon dioxide are described. The radiochemical yield (based on [__carbonyl__โ^11^C]โacetic acid), purity, and the specific activity (end of bombardment) of the
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