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Synthesis of n.c.a.[11C]sarin

โœ Scribed by C. Prenant; C. Crouzel


Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
55 KB
Volume
26
Category
Article
ISSN
0022-2135

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๐Ÿ“œ SIMILAR VOLUMES


Synthesis of [11C]-sarin
โœ C. Prenant; C. Crouzel ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 218 KB

## Abstract [^11^C]โ€acetone, prepared from ^11^CO~2~ and methyllithium, was reduced to [^11^C]โ€isopropanol. The latter reacted with methylphosphonic acid difluoride in the presence of diisopropylamine, to yield [11C]โ€sarin. 3.4 GBq (100 mCi) of [^11^C]โ€sarin may be obtained from about 55.5 GBq (1.

Synthesis of n.c.a.[11C]QNB
โœ C. Prenant; L. Barrรฉ; C. Crouzel ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 85 KB
Synthesis of [14C] Sarin
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## Abstract Synthetic routes for the synthesis of [^14^C] sarin and related nerve agents are described. Triethyl phosphite and [^14^C] methyl iodide are reacted in the Michaelisโ€“Arbusov reaction to produce diethyl methyl phosphonate which is converted to methylphosphonic acid by hydrolysis. After c

Synthesis of specific labelled [methyl-1
โœ A. Chang Sin-Ren; Gaetano Riggio; Wolfgang H. Hopff; Peter G. Waser ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 384 KB ๐Ÿ‘ 1 views

Synthesis o f specific labelled [methyl-14Clsarin. The synthesis of label led [methyl-14Clsarin, [14Clmethylphosphonofluoridic acid 1-methylethyl ester, was accomplished by another approach as for nonlabelled sarin in a tele-conducted reaction vessel. The purity was estimated by IR, GC, and GC-MS a

A concise synthesis of [carbonyl-11C]mel
โœ Masao Tada; Atsushi Oikawa; Ren Iwata; Kazunori Sato; Hiroshi Sugiyama; Hiromu T ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 218 KB

## Abstract Rapid chemical __syntheses of [carbonyl__โ€ ^11^C]melatonin and __N__โ€[__carbonyl__โ€ ^11^C]acetylserotonin starting from [^11^C]carbon dioxide are described. The radiochemical yield (based on [__carbonyl__โ€^11^C]โ€acetic acid), purity, and the specific activity (end of bombardment) of the

Enzymatic synthesis of [11C]N-acetylsero
โœ Geert Mannens; Guido Slegers; Patrick Goethals ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 294 KB ๐Ÿ‘ 1 views

## Abstract An enzymatic synthesis of [^11^C] __N__โ€acetylserotonin is described. [1โ€^11^C] acetate is produced by reacting ^11^CO~2~ with methylmagnesium bromide and converted to [^11^C]acetylCoA by passage over a first enzyme reactor containing immobilized acetylcoenzyme A synthetase. The produce