✦ LIBER ✦

Synthesis of [14C] Sarin

✍ Scribed by Rikard Norlin; Gösta Lindberg

Publisher: John Wiley and Sons
Year: 2003
Tongue: French
Weight: 78 KB
Volume: 46
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.699

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✦ Synopsis

Abstract

Synthetic routes for the synthesis of [^14^C] sarin and related nerve agents are described. Triethyl phosphite and [^14^C] methyl iodide are reacted in the Michaelis–Arbusov reaction to produce diethyl methyl phosphonate which is converted to methylphosphonic acid by hydrolysis. After chlorination and subsequent fluorination the final product is formed by reaction with the appropriate alcohol. Copyright © 2003 John Wiley & Sons, Ltd.

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