𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 14-14C-adriamycin

✍ Scribed by Babu R. Vishnuvajjala; Tadashi Kataoka; Frederick D. Cazer; Donald T. Witiak; Louis Malspeis

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
249 KB
Volume
14
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

14-14C-Adriamycin HC1 has been prepared from unlabeled adriamycin. The 14C-Diazald served as the source of the label. This synthesis does not require protection of the phenolic hydroxyl groups.

📜 SIMILAR VOLUMES

Synthesis of daunorubicin-14-14C and adr
Synthesis of daunorubicin-14-14C and adriamycin-14-14C
✍ C. Rolland Chen; Mary Tan Fon; Alan N. Fujiwara; David W. Henry; Morris A. Leaff 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 275 KB

## Abstract Reaction of adriamycinone with excess ^14^CH~3~Mgl and periodate cleavage of the resulting glycol (5) affords daunomycinone‐14‐^14^C (6). Bromination and hydrolysis of 6 gives adriamycinone‐14‐^14^C (8). Coupling of 6 and the 14‐0‐p‐anisyldiphenyl‐methyl derivative (9) with 1‐chloro‐3‐N

Synthesis of 14C-lanosterol and 14C-desm
Synthesis of 14C-lanosterol and 14C-desmosterol
✍ B. Danieli; G. Russo 📂 Article 📅 1965 🏛 John Wiley and Sons 🌐 French ⚖ 296 KB

The synthesis of lanosterol [la] and desmosterol [Ira] Iabeled with 14C in the 25 position by a Wittig reaction between triphenyl-214C isopropylidene-phosphorane [IVb] and the corresponding aldehydes are described. The specijic activities obtained are, respectively, 0.539 mClmM and 0.752 mClmM and t

Synthesis of 14C-hydroxyurea with immobi
Synthesis of 14C-hydroxyurea with immobilized 14C-cyanate
✍ Alfred M. Ajami 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 173 KB

## Abstract A solution of hydroxylamine hydrochloride is passed over a column bed of Amberlite IRA‐400 pre‐loaded with ^14^CNO^−^ anions. ^14^C‐hydroxyurea is formed in 50% radiochemical yield after recrystallization. The product is not contaminated with iso‐hydroxyurea or other by‐products usually

Synthesis of [14C]-fenfluramine and [14C
Synthesis of [14C]-fenfluramine and [14C]-S780
✍ D. R. Hawkins; I. Midgley 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 261 KB

## Abstract The syntheses of 1‐m‐trifluoromethylphenyl‐2‐N‐ethylaminopropane (I; Ponderax®) and 1‐m‐trifluoromethylphenyl‐2‐N‐β‐benzoyloxyethylaminopropane (II; S780) labelled with carbon‐14 at the benzylic position have been accomplished in seven stages starting from Ba^14^CO~3~. The overall radio

Synthesis of mycophenolate mofetil-[14C]
Synthesis of mycophenolate mofetil-[14C], RS-61443-14C
✍ Glenn T. Huang; Howard Parnes 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 384 KB

Synthesis of the potent immunosuppressive agent, mycophenolate mofetil (I) labelled with carbon-14 is described. Methoxyethoxymethyl (MEM) protected mycophenolate norbromide (2) was prepared from unlabelled mycophenolic acid (2) using a modified Hunsdiecker reaction. A three step synthesis furnished

Synthesis of [pyrrolidine-14C]-cotinine
Synthesis of [pyrrolidine-14C]-cotinine from 14C-nicotine
✍ R. Peeters; P. Daenens 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 242 KB

The synthesis and purification of 14C-cotinine is reported. 14C-nicotine is converted into 14C-dibromocotinine. Debromination of the latter results in 14C-cotinine which is purified by high performance liquid chromatography. The total radioactive yield of the synthesis is 44.8 %. Starting from 5