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Synthesis of [14C]-fenfluramine and [14C]-S780

✍ Scribed by D. R. Hawkins; I. Midgley

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
261 KB
Volume
10
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The syntheses of 1‐m‐trifluoromethylphenyl‐2‐N‐ethylaminopropane (I; Ponderax®) and 1‐m‐trifluoromethylphenyl‐2‐N‐β‐benzoyloxyethylaminopropane (II; S780) labelled with carbon‐14 at the benzylic position have been accomplished in seven stages starting from Ba^14^CO~3~. The overall radiochemical yield was 9% and both products were obtained with a radiochemical purity in excess of 98%.

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