𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of [pyrrolidine-14C]-cotinine from 14C-nicotine

✍ Scribed by R. Peeters; P. Daenens

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
242 KB
Volume
27
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

The synthesis and purification of 14C-cotinine is reported.

14C-nicotine is converted into 14C-dibromocotinine. Debromination of the latter results in 14C-cotinine which is purified by high performance liquid chromatography.

The total radioactive yield of the synthesis is 44.8 %.

Starting from 5 0 0 pCi 14C-nicotine, 224 pCi 14C-cotinine is obtained with a specific activity of 0,23 mCi/mmol.

📜 SIMILAR VOLUMES

A convenient synthesis of 14C-cotinine f
A convenient synthesis of 14C-cotinine from 14C-nicotine
✍ Dhimant H. Desai; Mirjana V. Djordjevic; Shantu Amin 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 198 KB

## Abstract A convenient synthesis with analytical monitoring of ^14^C‐cotinine is reported. ^14^C‐Nicotine was converted into ^14^C‐dibromocotinine hydrobromide perbromide. Debromination, achieved by using Zn dust/acetic acid, resulted in high yields (71%) of ^14^C‐cotinine.

Synthesis of pyrrolidine-2–14C
Synthesis of pyrrolidine-2–14C
✍ John M. Walts; Wayne V. Kessler; John E. Christian 📂 Article 📅 1967 🏛 John Wiley and Sons 🌐 English ⚖ 319 KB
Synthesis of daunorubicin-14-14C and adr
Synthesis of daunorubicin-14-14C and adriamycin-14-14C
✍ C. Rolland Chen; Mary Tan Fon; Alan N. Fujiwara; David W. Henry; Morris A. Leaff 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 275 KB

## Abstract Reaction of adriamycinone with excess ^14^CH~3~Mgl and periodate cleavage of the resulting glycol (5) affords daunomycinone‐14‐^14^C (6). Bromination and hydrolysis of 6 gives adriamycinone‐14‐^14^C (8). Coupling of 6 and the 14‐0‐p‐anisyldiphenyl‐methyl derivative (9) with 1‐chloro‐3‐N

Synthesis of [methyl-14C]crotonobetaine
Synthesis of [methyl-14C]crotonobetaine from DL-[methyl-14C]carnitine
✍ Heinz Löster; Hermann Seim 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 311 KB 👁 1 views

The causes of carnitine deficiency syndromes are not completely understood, but decomposition of L-carnitine in vivo is likely t o be involved. Carnitine is metabolized to y-butyrobetaine, and crotonobetaine is probably an intermediate in this pathway. To validate experimentally the precursor-produc

Synthesis of [1-14C]-2,2-difluoroethene
Synthesis of [1-14C]-2,2-difluoroethene from [14C]-formaldehyde
✍ Jan A. Ruzicka; Weiming Qiu; Max T. Baker; Donald J. Burton 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 231 KB

## Abstract [1‐^14^C]‐2,2‐Difluoroethene was synthesized from [^14^C]‐formaldehyde using a modification of the Wadsworth‐Emmons reaction, __via__ formation of the intermediate (EtO)~2~P(O)CF~2~^14^CH~2~OSiMe~3~. This highly volatile product was collected in a liquid nitrogen trap at a purity of >97