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Synthesis of [1-14C]-2,2-difluoroethene from [14C]-formaldehyde

✍ Scribed by Jan A. Ruzicka; Weiming Qiu; Max T. Baker; Donald J. Burton

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
231 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[1‐^14^C]‐2,2‐Difluoroethene was synthesized from [^14^C]‐formaldehyde using a modification of the Wadsworth‐Emmons reaction, via formation of the intermediate (EtO)~2~P(O)CF~2~^14^CH~2~OSiMe~3~. This highly volatile product was collected in a liquid nitrogen trap at a purity of >97% and specific activity of 0.2 mCi/mmol, with yields of 10 ‐ 15%.

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