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Synthesis of [thiazolium-2,2′-14C2]-SAR97276A from [14C]-thiourea

✍ Scribed by John M. Herbert; Franck Le Strat; Delphine G. Oumeddour; Stephen C. Passey; Keith Taylor; David M. Whitehead

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
103 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[thiazolium‐2,2′‐^14^C~2~]‐SAR97276A, a bis(thiazolium) antimalarial development candidate, was synthesized from [^14^C]‐thiourea with an overall radiochemical yield of 15%. The synthetic route involves a modified procedure for the synthesis of [^14^C]‐sulfurol, also a key intermediate in thiamine synthesis, which was developed due to unlabelled chemistry proving irreproducible with the radiolabelled substrate. Copyright © 2010 John Wiley & Sons, Ltd.

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