Synthesis of 5,5-dimethyl-2,4-oxazolidinedione-2-C14 (DMO-2-C14)
✍ Scribed by Thomas C. Butler; Jack D. Davidson
- Publisher
- John Wiley and Sons
- Year
- 1963
- Tongue
- English
- Weight
- 226 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0022-3549
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## Abstract 2,2′,5′,2″– [2′,5′ – ^14^C~2~] Terthienyl and 1,4–Bis (2–Thienl) [1,4–^14^C~2~] butadiyne were synthesized from [14~C~] formic acid.
## Abstract Diethyl ethoxymethylenemalonate was condensed with thiourea−^14^C in the presence of sodium ethylate to give ethyl 2‐thio‐6‐oxypyrimidine‐5‐carboxylate‐2−^14^C. Desulfurization of the latter pyrimidine with chloroacetic acid gave uracil‐5‐carboxylic acid‐2−^14^C, which was subsequently
## Abstract A convenient synthesis of the pharmacological intermediate 2‐pyrrolidione‐5‐^14^C, was developed using potassium cyanide ^14^C as starting material. Potassim cyanide‐^14^C was converted to 2‐pyrrolidinone‐5‐^14^C in an overall 56% radiochemical yield.